Open AccessCCR9+ and CD103+ tolerogenic dendritic cell populations in food allergy patients undergoing oral immunotherapy
Author(s) -
Garcia Marco,
Singh Amit,
Yu Grace,
Bucayu Robi,
Longbottom Trevor,
Nadeau Kari
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-o51
Subject(s) - oral immunotherapy , medicine , immunotherapy , food allergy , allergy , immunology , dendritic cell , antigen , immune system
Rationale CD103+ DCs (dendritic cells) and CCR9+ pDCs (plasmacytoid DCs) have been implicated in promoting tolerance to antigens through regulatory-T cell induction. We have conducted food oral immunotherapy (OIT) clinical studies for the last 3 years at Stanford University. We hypothesized that subjects with food allergies have low CD103+ and CCR9+ expression on their DCs but that these DC populations change over time while on therapy.