Open AccessAngiotensin converting enzyme‐gene polymorphisms in normal subjects, atopic individuals and those with anaphylaxis to venom, food and drugs
Author(s) -
Varney Veronica,
Warner Amena,
Ghosh Angeli,
Nicholas Alex,
Sumar Nazira
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-o45
Subject(s) - medicine , anaphylaxis , allergy , venom , food allergy , gene , immunology , angiotensin converting enzyme , pharmacology , genetics , biology , biochemistry , blood pressure
Background Circulating angiotensin-2 levels (A2) protect the circulation against sudden falls in blood pressure. A2 is generated by the enzymatic action of angiotensin converting enzyme (ACE) on angiotensin-1. The ACE genes have 2 allellic forms, with the presence ‘I’ or absence ‘D’ of a 287 base pair intron of the gene. The deletion ‘DD’ genotype is associated with high A2 generation & higher serum ACE levels, while the insertion ‘I I’ with lower serum ACE levels & ACE activity.