Open AccessPositive food challenges despite negative specific IgE testing
Author(s) -
Makatsori Melina,
Scadding Guy,
McKenzie Rebecca,
Skypala Isabel,
Durham Stephen
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-o42
Subject(s) - medicine , gold standard (test) , food allergy , immunoglobulin e , oral food challenge , immunology , food allergens , allergy , intensive care medicine , antibody
Background Skin prick testing and serum food-specific IgE testing are the most commonly used diagnostic tests in evaluating IgE-mediated food reactions. However, the presence of negative tests can be falsely re-assuring such outcomes do not always exclude allergy. Food challenges are therefore indicated. Double-blind, placebo-controlled food challenge is the gold standard for diagnosis, but in many situations, open food challenges are a more practical alternative.