Open AccessFish allergy‐natural history and crossreactivity between fish species
Author(s) -
Stavroulakis George,
Giavi Stavroula,
Douladiris Nikolaos,
Manousakis Manolis,
Papadopoulos Nikolaos G
Publication year - 2011
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-1-s1-o26
Subject(s) - swordfish , tuna , fish <actinopterygii> , allergy , medicine , food allergy , allergen , natural history , fishery , food science , biology , immunology
Material and methods 105 children with a diagnosis of type I allergy to fish, based on history, specific IgE (sIgE, CAP) to codfish (f3) and skin prick tests (SPT) with commercial fish extracts, are included so far. All children undergo open food challenges (OFC) with canned tuna, fresh swordfish or fresh tuna in order to evaluate whether these fishes are tolerated or not by fish allergic children. Subsequently, those children showing signs of reduced clinical reactivity are subjected to double blind placebo controlled food challenges (DBPCFC) with codfish, followed by OFC to codfish in those with a negative DBPCFC, to evaluate the natural history.