Allergy as an epithelial barrier disease | Zendy

Mattila Pirkko | Zendy; Joenväärä Sakari | Zendy; Renkonen Jutta | Zendy; ToppilaSalmi Sanna | Zendy; Renkonen Risto | Zendy

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Allergy as an epithelial barrier disease

Author(s) -

Mattila Pirkko,

Joenväärä Sakari,

Renkonen Jutta,

ToppilaSalmi Sanna,

Renkonen Risto

Publication year - 2011

Publication title -

clinical and translational allergy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.979

H-Index - 37

ISSN - 2045-7022

DOI - 10.1186/2045-7022-1-5

Subject(s) - medicine , allergy , disease , skin barrier , immunology , dermatology , pathology

The objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic reaction. We review the literature of the role of respiratory epithelium as an active barrier, how allergens are transported through it and how it senses the hostile environmental allergens and other dangerous stimuli.

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