Open AccessPluripotent muse cells derived from human adipose tissue: a new perspective on regenerative medicine and cell therapy
Author(s) -
Simerman Ariel A,
Dumesic Daniel A,
Chazenbalk Gregorio D
Publication year - 2014
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/2001-1326-3-12
Subject(s) - induced pluripotent stem cell , regenerative medicine , embryonic stem cell , stem cell , adipose tissue , microbiology and biotechnology , adult stem cell , biology , cell therapy , germ layer , cancer research , medicine , endocrinology , genetics , gene
In 2010, Multilineage Differentiating Stress Enduring (Muse) cells were introduced to the scientific community, offering potential resolution to the issue of teratoma formation that plagues both embryonic stem (ES) and induced pluripotent (iPS) stem cells. Isolated from human bone marrow, dermal fibroblasts, adipose tissue and commercially available adipose stem cells (ASCs) under severe cellular stress conditions, Muse cells self‐renew in a controlled manner and do not form teratomas when injected into immune‐deficient mice. Furthermore, Muse cells express classic pluripotency markers and differentiate into cells from the three embryonic germ layers both spontaneously and under media‐specific induction. When transplanted in vivo , Muse cells contribute to tissue generation and repair. This review delves into the aspects of Muse cells that set them apart from ES, iPS, and various reported adult pluripotent stem cell lines, with specific emphasis on Muse cells derived from adipose tissue (Muse‐AT), and their potential to revolutionize the field of regenerative medicine and stem cell therapy.