The Abnormal Measures of Iron Homeostasis in Pediatric Obesity Are Associated with the Inflammation of Obesity
Author(s) -
MatthewW Richardson,
Leybie Ang,
PaulF Visintainer,
ChrystalA Wittcopp
Publication year - 2009
Publication title -
international journal of pediatric endocrinology/international journal of pediatric endocrinology
Language(s) - English
Resource type - Journals
eISSN - 1687-9856
pISSN - 1687-9848
DOI - 10.1186/1687-9856-2009-713269
Subject(s) - medicine , obesity , iron homeostasis , inflammation , bioinformatics , pediatrics , intensive care medicine , metabolism , biology
Objectives. To determine if the low iron state described in obese children is associated with the chronic inflammatory state seen in obesity. Study Design. Obese children age from 2 to 19 years seen at a weight management clinic were studied prospectively. Data were collected on age, gender, BMI, BMI -score, serum iron, ferritin, transferrin saturation, free erythrocyte protoporphyrin, high sensitivity creactive protein (hs-crp), and hemoglobin concentration. Results. 107 subjects were studied. Hs-crp levels correlated positively with BMI and BMI -score and negatively with serum iron . 11.2% of subjects had low serum iron. Median serum iron was significantly lower for subjects with American Heart Association high risk hs-crp values (3 mg/L) compared to those with low risk hs-crp (1 mg/L), (65 mcg/dL versus 96 mcg/dL, ). After adjusting for age, gender, and BMI -score, serum iron was still negatively associated with hs-crp . Conclusions. We conclude that the chronic inflammation of obesity results in the low iron state previously reported in obese children, similar to what is seen in other inflammatory diseases.
Open Access