Open AccessFSH Injections and Ultrasonography Determine Presence of Ovarian Components in the Evaluation of Ovotesticular Disorders of Sex Development
Author(s) -
Shan E. French,
Luisa Fernanda Rodríguez,
Alan E. Schlesinger,
Laurence B. McCullough,
Jennifer E. Dietrich,
John Hicks,
Lefkothea Karaviti
Publication year - 2009
Publication title -
international journal of pediatric endocrinology/international journal of pediatric endocrinology
Language(s) - English
Resource type - Journals
eISSN - 1687-9856
pISSN - 1687-9848
DOI - 10.1186/1687-9856-2009-507964
Subject(s) - medicine , ultrasonography , disorders of sex development , gynecology , pediatrics , surgery
Three infants with ambiguous genitalia and suspected ovotestes were given recombinant FSH to induce ovarian follicular development. The development of follicles in the gonadal tissue suggested the presence of ovarian tissue in two of the three infants. This method may provide a means to better characterize gonadal anatomy in patients affected by disorders of sex development (DSD). Sonographic information poststimulation provided parents with earlier and more specific education and support concerning the possible need for confirmative gonadal biopsy treatment options.