Open AccessDecreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy
Author(s) -
Minke A.E. Rab,
Jennifer Bos,
Brigitte A. van Oirschot,
Stephanie van Straaten,
Penelope A. Kosinski,
Victor Chubukov,
Hyeryun Kim,
Heidi Mangus,
Roger E. G. Schutgens,
Gerard Pasterkamp,
Lenny Dang,
Charles Kung,
Eduard J. van Beers,
Richard van Wijk
Publication year - 2021
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2020008635
Subject(s) - pyruvate kinase , pyruvate kinase deficiency , medicine , disease , glycolysis , metabolism
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom