Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis | Zendy

Zemin Ren | Zendy; Marcel Spaargaren | Zendy; Steven T. Pals | Zendy

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Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis

Author(s) -

Zemin Ren,

Marcel Spaargaren,

Steven T. Pals

Publication year - 2021

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2020008188

Subject(s) - syndecan 1 , plasma cell , stromal cell , multiple myeloma , microbiology and biotechnology , bone marrow , proteoglycan , biology , heparan sulfate , tumor microenvironment , immunology , cancer research , cell , biochemistry , extracellular matrix , immune system

Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma.

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