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Impact of TKIs post–allogeneic hematopoietic cell transplantation in Philadelphia chromosome–positive ALL
Author(s) -
Neeraj Saini,
David Marín,
Celina Ledesma,
Ruby Delgado,
Gabriela Rondón,
Uday Popat,
Qaiser Bashir,
Chitra Hosing,
Yago Nieto,
Amin M. Alousi,
Muzaffar H. Qazilbash,
Stefan O. Ciurea,
Elizabeth Shpall,
Issa F. Khouri,
Hagop M. Kantarjian,
Elias Jabbour,
Farhad Ravandi,
Richard E. Champlin,
Partow Kebriaei
Publication year - 2020
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019004685
Subject(s) - transplantation , philadelphia chromosome , hematopoietic stem cell transplantation , medicine , stem cell , tyrosine kinase , immunology , biology , genetics , chromosomal translocation , gene , receptor
How to best use tyrosine kinase inhibitors (TKIs) of BCR-ABL after allogeneic stem cell transplantation for Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL) is unknown but will almost certainly not be addressed by a definitive randomized trial. Saini and colleagues provide a large body of observational data to reinforce earlier circumstantial evidence favoring prophylactic use of TKIs for at least 2 years posttransplant.

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