Preleukemic and leukemic evolution at the stem cell level | Zendy

Jacob Stauber | Zendy; John M. Greally | Zendy; Ulrich Steidl | Zendy

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Preleukemic and leukemic evolution at the stem cell level

Author(s) -

Jacob Stauber,

John M. Greally,

Ulrich Steidl

Publication year - 2020

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019004397

Subject(s) - somatic evolution in cancer , biology , stem cell , population , haematopoiesis , disease , leukemia , preleukemia , evolutionary biology , genetics , immunology , cancer , medicine , pathology , environmental health

Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.

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