Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia | Zendy

Benshang Li | Zendy; Samuel W. Brady | Zendy; Xiaotu Ma | Zendy; Shuhong Shen | Zendy; Yingchi Zhang | Zendy; Yongjin Li | Zendy; Karol Szlachta | Zendy; Li Dong | Zendy; Yu Liu | Zendy; Fan Yang | Zendy; Ningling Wang | Zendy; Diane A. Flasch | Zendy; Matthew A. Myers | Zendy; Heather L. Mulder | Zendy; Lixia Ding | Zendy; Yanling Liu | Zendy; Liqing Tian | Zendy; Kohei Hagiwara | Zendy; Ke Xu | Zendy; Xin Zhou | Zendy; Edgar Sioson | Zendy; Tianyi Wang | Zendy; Liu Yang | Zendy; Jie Zhao | Zendy; Hui Zhang | Zendy; Ying Shao | Zendy; Hongye Sun | Zendy; Lele Sun | Zendy; Jiaoyang Cai | Zendy; Hui-Ying Sun | Zendy; Ting-Nien Lin | Zendy; Lijuan Du | Zendy; Hui Li | Zendy; Michael Rusch | Zendy; Michael N. Edmonson | Zendy; John Easton | Zendy; Xiaofan Zhu | Zendy; Jingliao Zhang | Zendy; Cheng Cheng | Zendy; Benjamin J. Raphael | Zendy; Jingyan Tang | Zendy; James R. Downing | Zendy; Ludmil B. Alexandrov | Zendy; Bin-Bing S. Zhou | Zendy; ChingHon Pui | Zendy; Jun J. Yang | Zendy; Jinghui Zhang | Zendy

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Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Author(s) -

Benshang Li,

Samuel W. Brady,

Xiaotu Ma,

Shuhong Shen,

Yingchi Zhang,

Yongjin Li,

Karol Szlachta,

Li Dong,

Yu Liu,

Fan Yang,

Ningling Wang,

Diane A. Flasch,

Matthew A. Myers,

Heather L. Mulder,

Lixia Ding,

Yanling Liu,

Liqing Tian,

Kohei Hagiwara,

Ke Xu,

Xin Zhou,

Edgar Sioson,

Tianyi Wang,

Liu Yang,

Jie Zhao,

Hui Zhang,

Ying Shao,

Hongye Sun,

Lele Sun,

Jiaoyang Cai,

Hui-Ying Sun,

Ting-Nien Lin,

Lijuan Du,

Hui Li,

Michael Rusch,

Michael N. Edmonson,

John Easton,

Xiaofan Zhu,

Jingliao Zhang,

Cheng Cheng,

Benjamin J. Raphael,

Jingyan Tang,

James R. Downing,

Ludmil B. Alexandrov,

Bin-Bing S. Zhou,

ChingHon Pui,

Jun J. Yang,

Jinghui Zhang

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019002220

Subject(s) - lymphoblastic leukemia , acute lymphocytic leukemia , chemotherapy , mutation , oncology , chemotherapy regimen , leukemia , cancer research , medicine , immunology , biology , genetics , gene

Li and colleagues report the genomic landscape of over 100 patients with relapsed acute lymphoblastic leukemia. Analysis of diagnosis-relapse-remission trios suggest that whereas early relapse is mediated by retained subclones, late relapse is driven by mutations induced by and conferring resistance to chemotherapy.

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