Open AccessMetabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor–tissue factor axis
Author(s) -
Mostafa Belghasem,
Daniel Röth,
Sean Richards,
Marc Arthur Napolene,
Joshua Walker,
Wenqing Yin,
Nkiruka Arinze,
Chimera Lyle,
Cheryl Spencer,
Jean Francis,
Cristal Reyna Thompson,
Chris Andry,
Stephen A. Whelan,
Norman Lee,
Katya Ravid,
Vipul C. Chitalia
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001675
Subject(s) - thrombogenicity , venous thrombosis , aryl hydrocarbon receptor , cancer , medicine , venous thromboembolism , tissue factor , mechanism (biology) , cancer research , thrombosis , chemistry , biochemistry , epistemology , coagulation , philosophy , gene , transcription factor
Currently, we have insufficient understanding of venous thromboembolism in cancer patients. In this article, the authors reveal a novel mechanism for colon cancer-associated venous thrombosis using a murine model.
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