Open AccessSalt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo
Author(s) -
Yusuke Tarumoto,
Shan Lin,
Jinhua Wang,
Joseph P. Milazzo,
Yali Xu,
Bin Lü,
Zhaolin Yang,
Yiliang Wei,
Sofya A. Polyanskaya,
Mark Wunderlich,
Nathanael S. Gray,
Kimberly Stegmaier,
Christopher R. Vakoc
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001576
Subject(s) - myeloid leukemia , cancer research , biology , mef2c , transcription factor , genetics , gene
Transcription factors are important drivers in acute myeloid leukemia (AML), but they are notoriously difficult to target. The authors demonstrate that inhibition of salt-inducible kinase (SIK3) inhibits AML cell proliferation in cells dependent on the transcription factor MEF2C, identifying a small molecule that can disrupt a leukemogenic transcription factor pathway.
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