Open AccessCohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies
Author(s) -
Daniel Sasca,
Haiyang Yun,
George Giotopoulos,
Jakub Szybinski,
Theodore Evan,
Nicola K. Wilson,
Moritz Gerstung,
Paolo Gallipoli,
Anthony R Green,
Robert K. Hills,
Nigel H. Russell,
Cameron S. Osborne,
Elli Papaemmanuil,
Berthold Göttgens,
Peter J. Campbell,
Brian J.P. Huntly
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001553
Subject(s) - cohesin , myeloid leukemia , myeloid , biology , cancer research , genetics , microbiology and biotechnology , gene , chromatin
Cohesin mutations are common in myeloid malignancy. Sasca et al elucidate the potential role of cohesin loss in myelodysplastic syndrome and acute myeloid leukemia (MDS/AML). They demonstrate that cohesin binding is critical for erythroid-specific gene expression and that reduction in cohesin impairs terminal erythroid maturation and promotes myeloid malignancy.
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