Open AccessSynergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy
Author(s) -
Liang Zheng,
Di Zhang,
Wenjing Cao,
WenChao Song,
X. Long Zheng
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001040
Subject(s) - thrombotic microangiopathy , adamts13 , alternative complement pathway , thrombotic thrombocytopenic purpura , complement system , pathogenesis , atypical hemolytic uremic syndrome , complement membrane attack complex , immunology , microangiopathic hemolytic anemia , medicine , von willebrand factor , platelet , immune system , disease
This study in mice suggests a synergistic role of ADAMTS13 deficiency and complement “hyperactivatability” in the pathogenesis of thrombotic microangiopathy.
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