Open AccessDonor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation
Author(s) -
Stavros Loukogeorgakis,
Camila Girardi Fachin,
André Ivan Bradley dos Santos Dias,
Haiying Li,
Li Tang,
Aimee G. Kim,
Jesse D. Vrecenak,
John D. Stratigis,
Nicholas J. Ahn,
Ilaissim,
Izhtak Nissim,
Antônio Fernandes Moron,
José Luiz Martins,
William H. Peranteau,
Paolo De Coppi,
Darrell J. Irvine,
Alan W. Flake
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001037
Subject(s) - transplantation , stem cell , gsk 3 , in utero , gsk3b , cancer research , chemistry , immunology , medicine , microbiology and biotechnology , biology , kinase , fetus , pregnancy , genetics
Intrauterine transplantation induces tolerance in the setting of the immature immue system but is hampered by low levels of engraftment. Glycogen synthase kinase 3 (GSK3) inhibition enhances stem cell proliferation, and Loukogeorgakis and colleagues report excellent engraftment in utero in mice following surface attachment of nanoparticles loaded with GSK3 inhibitor to donor stem cells.
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