Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry
Author(s) -
Catalina Amador,
Timothy C. Greiner,
Tayla B. Heavican,
Lynette M. Smith,
Karen Galvis,
Waseem Lone,
Alyssa Bouska,
Francesco d’Amore,
Martin Bjerregård Pedersen,
Stefano Pileri,
Claudio Agostinelli,
Andrew L. Feldman,
Andreas Rosenwald,
German Ott,
Anja Mottok,
Kerry J. Savage,
Laurence de Leval,
Philippe Gaulard,
Soon Thye Lim,
Choon Kiat Ong,
Sarah L. Ondrejka,
Joo Y. Song,
Elı́as Campo,
Elaine S. Jaffe,
Louis M. Staudt,
Lisa M. Rimsza,
Julie M. Vose,
Dennis D. Weisenburger,
Wing C. Chan,
Javeed Iqbal
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019000779
Subject(s) - immunohistochemistry , peripheral t cell lymphoma , medicine , gata3 , lymphoma , international prognostic index , oncology , pathology , t cell , biology , diffuse large b cell lymphoma , immunology , immune system , gene , biochemistry , transcription factor
One-third of peripheral T-cell lymphomas are “not otherwise specified” (PTCL-NOS), but they have been subdivided into 2 subgroups based on gene expression profiling. Amador and colleagues generated an immunohistochemical algorithm that parallels the molecular separation of PTCL-NOS and provides useful prognostic information.
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