Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice | Zendy

Seungwon Lee | Zendy; Hyekang Kim | Zendy; Gihoon You | Zendy; YoungMin Kim | Zendy; SeungHun Lee | Zendy; VietHoan Le | Zendy; Ohseop Kwon | Zendy; SinHyeog Im | Zendy; YouMe Kim | Zendy; Kwang Soon Kim | Zendy; Young Chul Sung | Zendy; Ki Hean Kim | Zendy; Charles D. Surh | Zendy; Yunji Park | Zendy; SeungWoo Lee | Zendy

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Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice

Author(s) -

Seungwon Lee,

Hyekang Kim,

Gihoon You,

YoungMin Kim,

SeungHun Lee,

VietHoan Le,

Ohseop Kwon,

SinHyeog Im,

YouMe Kim,

Kwang Soon Kim,

Young Chul Sung,

Ki Hean Kim,

Charles D. Surh,

Yunji Park,

SeungWoo Lee

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019000495

Subject(s) - bone marrow , haematopoiesis , progenitor cell , peripheral blood mononuclear cell , immunology , biology , myeloid , microbiology and biotechnology , cx3cr1 , cytokine , chemokine , stem cell , inflammation , chemokine receptor , genetics , in vitro

Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.

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