Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia | Zendy

Antonio R. LucenaAraujo | Zendy; Juan Luiz CoelhoSilva | Zendy; Diego A. PereiraMartins | Zendy; Douglas RA Silveira | Zendy; Luisa C A Koury | Zendy; Raul Antônio Morais Melo | Zendy; Rosane Bittencourt | Zendy; Kátia Bórgia Barbosa Pagnano | Zendy; Ricardo Pasqüini | Zendy; Elenaide C. Nunes | Zendy; Evandro M. Fagundes | Zendy; Ana Glória | Zendy; Fábio R. Kerbauy | Zendy; Maria de Lourdes Chauffaille | Zendy; Israel Bendit | Zendy; Vanderson Rocha | Zendy; Armand Keating | Zendy; Martin S. Tallman | Zendy; Raul C. Ribeiro | Zendy; Richard Dillon | Zendy; Arnold Ganser | Zendy; Bob Löwenberg | Zendy; Peter J.M. Valk | Zendy; Francesco LoCoco | Zendy; Miguel Á. Sanz | Zendy; Nancy Berliner | Zendy; Eduardo Magalhães Rego | Zendy

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Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia

Author(s) -

Antonio R. LucenaAraujo,

Juan Luiz CoelhoSilva,

Diego A. PereiraMartins,

Douglas RA Silveira,

Luisa C A Koury,

Raul Antônio Morais Melo,

Rosane Bittencourt,

Kátia Bórgia Barbosa Pagnano,

Ricardo Pasqüini,

Elenaide C. Nunes,

Evandro M. Fagundes,

Ana Glória,

Fábio R. Kerbauy,

Maria de Lourdes Chauffaille,

Israel Bendit,

Vanderson Rocha,

Armand Keating,

Martin S. Tallman,

Raul C. Ribeiro,

Richard Dillon,

Arnold Ganser,

Bob Löwenberg,

Peter J.M. Valk,

Francesco LoCoco,

Miguel Á. Sanz,

Nancy Berliner,

Eduardo Magalhães Rego

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019000239

Subject(s) - acute promyelocytic leukemia , myeloid leukemia , anthracycline , oncology , medicine , retinoic acid , mutation , tretinoin , daunorubicin , gene , leukemia , malignancy , cancer research , bioinformatics , genetics , biology , cancer , breast cancer

Luceno-Araujo et al use assays of mutations associated with myeloid malignancy to propose an integrative prognostic score for acute promyelocytic leukemia (ISAPL) in patients treated with all-trans retinoic acid and anthracycline-based therapy. They demonstrate that the ISAPL is superior for predicting outcomes and identifying patients who may benefit from alternative therapies to maximize their chance of a cure.

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