Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis | Zendy

Sascha Geue | Zendy; Katja Aurbach | Zendy; Mailin-Christin Manke | Zendy; Georgi Manukjan | Zendy; Patrick Münzer | Zendy; David Stegner | Zendy; Caroline Brähler | Zendy; Britta Walker-Allgaier | Zendy; Melanie Märklin | Zendy; Carla E. Borst | Zendy; Leticia QuintanillaMartínez | Zendy; Dominik Rath | Zendy; Tobias Geisler | Zendy; Helmut R. Salih | Zendy; Peter Seizer | Zendy; Florian Läng | Zendy; Bernhard Nieswandt | Zendy; Meinrad Gawaz | Zendy; Harald Schulze | Zendy; Irina Pleines | Zendy; Oliver Borst | Zendy

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Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

Author(s) -

Sascha Geue,

Katja Aurbach,

Mailin-Christin Manke,

Georgi Manukjan,

Patrick Münzer,

David Stegner,

Caroline Brähler,

Britta Walker-Allgaier,

Melanie Märklin,

Carla E. Borst,

Leticia QuintanillaMartínez,

Dominik Rath,

Tobias Geisler,

Helmut R. Salih,

Peter Seizer,

Florian Läng,

Bernhard Nieswandt,

Meinrad Gawaz,

Harald Schulze,

Irina Pleines,

Oliver Borst

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019000185

Subject(s) - megakaryocyte , cytoskeleton , microbiology and biotechnology , biogenesis , platelet , biology , thrombopoiesis , chemistry , haematopoiesis , immunology , cell , biochemistry , stem cell , gene

The investigators explore the role of PDK1 (phosphoinositide-dependent protein kinase 1) in the cytoskeletal regulation of platelet production and furnish new insights into megakaryocyte maturation and proplatelet formation.

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