γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma | Zendy

Margot J. Pont | Zendy; Tyler J. Hill | Zendy; Gabriel O. Cole | Zendy; Joe James Abbott | Zendy; Jessica L. Kelliher | Zendy; Alexander I. Salter | Zendy; Michael Hudecek | Zendy; Melissa L. Comstock | Zendy; Anusha Rajan | Zendy; Bharvin K.R. Patel | Zendy; Jenna Voutsinas | Zendy; Qian Wu | Zendy; Lingfeng Liu | Zendy; Andrew J. Cowan | Zendy; Brent L. Wood | Zendy; Damian J. Green | Zendy; Stanley R. Riddell | Zendy

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γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma

Author(s) -

Margot J. Pont,

Tyler J. Hill,

Gabriel O. Cole,

Joe James Abbott,

Jessica L. Kelliher,

Alexander I. Salter,

Michael Hudecek,

Melissa L. Comstock,

Anusha Rajan,

Bharvin K.R. Patel,

Jenna Voutsinas,

Qian Wu,

Lingfeng Liu,

Andrew J. Cowan,

Brent L. Wood,

Damian J. Green,

Stanley R. Riddell

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019000050

Subject(s) - chimeric antigen receptor , cancer research , medicine , antigen , t cell , multiple myeloma , immunology , immune system

Despite notably high response rates to B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells in multiple myeloma, few patients have a sustained, very good partial or complete response. This article presents a novel strategy to increase the efficacy of BCMA-directed CAR T-cell therapy and shows that γ-secretase inhibitors improve the efficacy of BCMA CAR T cells by increasing BCMA expression and reducing soluble BCMA.

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