Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes | Zendy

Stosh Ozog | Zendy; Nina Timberlake | Zendy; Kip Hermann | Zendy; Olivia Garijo | Zendy; Kevin G. Haworth | Zendy; Guoli Shi | Zendy; Christopher M. Glinkerman | Zendy; Lauren E. Schefter | Zendy; Saritha S. D’Souza | Zendy; Elizabeth M. Simpson | Zendy; Gabriella Sghia-Hughes | Zendy; Raymond R. Carillo | Zendy; Dale L. Boger | Zendy; HansPeter Kiem | Zendy; Igor I. Slukvin | Zendy; Byoung Y. Ryu | Zendy; Brian P. Sorrentino | Zendy; Jennifer E. Adair | Zendy; Scott A. Snyder | Zendy; Alex A. Compton | Zendy; Bruce E. Torbett | Zendy

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Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes

Author(s) -

Stosh Ozog,

Nina Timberlake,

Kip Hermann,

Olivia Garijo,

Kevin G. Haworth,

Guoli Shi,

Christopher M. Glinkerman,

Lauren E. Schefter,

Saritha S. D’Souza,

Elizabeth M. Simpson,

Gabriella Sghia-Hughes,

Raymond R. Carillo,

Dale L. Boger,

HansPeter Kiem,

Igor I. Slukvin,

Byoung Y. Ryu,

Brian P. Sorrentino,

Jennifer E. Adair,

Scott A. Snyder,

Alex A. Compton,

Bruce E. Torbett

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2019000040

Subject(s) - endosome , haematopoiesis , stem cell , gene delivery , microbiology and biotechnology , viral vector , biology , progenitor cell , resveratrol , hematopoietic stem cell , interferon , transmembrane protein , gene , genetic enhancement , cancer research , chemistry , virology , pharmacology , biochemistry , recombinant dna , receptor , intracellular

Key Points The cyclic resveratrol trimer caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A decreases interferon-induced transmembrane protein-mediated restriction in an endosomal trafficking-dependent manner.

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