Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis | Zendy

Nermi L. Parrow | Zendy; Yihang Li | Zendy; Maria Feola | Zendy; Amaliris Guerra | Zendy; Carla Casu | Zendy; Princy Prasad | Zendy; Luke Mammen | Zendy; Faris Ali | Zendy; Edvinas Vaicikauskas | Zendy; Stefano Rivella | Zendy; Yelena Ginzburg | Zendy; Robert E. Fleming | Zendy

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Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

Author(s) -

Nermi L. Parrow,

Yihang Li,

Maria Feola,

Amaliris Guerra,

Carla Casu,

Princy Prasad,

Luke Mammen,

Faris Ali,

Edvinas Vaicikauskas,

Stefano Rivella,

Yelena Ginzburg,

Robert E. Fleming

Publication year - 2019

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2018893099

Subject(s) - erythropoiesis , hepcidin , transferrin , erythropoietin , zinc protoporphyrin , endocrinology , microcytosis , medicine , transferrin receptor , red blood cell , hemoglobin , biology , anemia , chemistry , iron deficiency , heme , biochemistry , enzyme

In this Plenary Paper, the investigators demonstrate that the two monoferric forms of transferrin, the major plasma glycoprotein involved in cellular iron delivery, have functionally distinct effects on erythropoiesis and systemic iron regulation.

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