Long-term psychological consequences of stroke (OX-CHRONIC): A longitudinal study of cognition in relation to mood and fatigue after stroke: Protocol | Zendy

Nele Demeyere | Zendy; Owen A. Williams | Zendy; Elise Milosevich | Zendy; Evangeline G. Chiu | Zendy; Bogna Drozdowska | Zendy; Avril Dillon | Zendy; Helen Dawes | Zendy; Shirley Thomas | Zendy; Annapoorna Kuppuswamy | Zendy; Sarah T. Pendlebury | Zendy; Terence J. Quinn | Zendy

Open Access

Long-term psychological consequences of stroke (OX-CHRONIC): A longitudinal study of cognition in relation to mood and fatigue after stroke: Protocol

Author(s) -

Nele Demeyere,

Owen A. Williams,

Elise Milosevich,

Evangeline G. Chiu,

Bogna Drozdowska,

Avril Dillon,

Helen Dawes,

Shirley Thomas,

Annapoorna Kuppuswamy,

Sarah T. Pendlebury,

Terence J. Quinn

Publication year - 2021

Publication title -

european stroke journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 16

eISSN - 2396-9881

pISSN - 2396-9873

DOI - 10.1177/23969873211046120

Subject(s) - mood , cognition , quality of life (healthcare) , stroke (engine) , neuropsychology , clinical psychology , cohort , psychology , medicine , psychiatry , physical therapy , physical medicine and rehabilitation , psychotherapist , mechanical engineering , engineering

Background The long-term psychological consequences of stroke and how cognitive problems change over time after the first-year following stroke remain unclear. Particularly, trajectories of domain-specific and domain-general cognitive functions and how cognition interacts with mood, fatigue and quality of life are not well described.Aims To determine the prevalence, trajectories and wider impact of domain-specific cognitive impairment in long-term stroke survivors, in relation to mood, fatigue and quality of life.Methods Participants who previously took part in the Oxford Cognitive Screening study, completed the 6-month follow-up with cognitive, mood, fatigue and quality of life assessments and agreed to be contacted for future research will be recruited into OX-CHRONIC. The eligible cohort is between 2- and 9-years post-stroke. Cognition will be assessed with a detailed neuropsychological battery, alongside questionnaire measures of mood, fatigue, activities of daily life and quality of life measures at two timepoints, 1 year apart. Additionally, medical records will be accessed to extract further clinical information about the stroke and patients may opt-in to wear an activity monitor for 1 week to provide fine-grained measures of sleep and activity. The study protocol and study materials were approved by the national ethics committee (REC Ref: 19/SC/0520).Planned outputs OX-CHRONIC will provide detailed data on the evolving cognitive profiles of stroke survivors over several years post-stroke. Estimates of long-term prevalence as well as the effect of changes in cognitive profiles on mood, fatigue and quality of life will be examined. This study is funded by a Priority Programme Grant from the Stroke Association (SA PPA 18/100032).

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