Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country | Zendy

Hamideh Khazraiyan | Zendy; Zahra Abdi Liaei | Zendy; Hamid Emadi Koochak | Zendy; Farid Azmoudeh Ardalan | Zendy; Zahra Ahmadinejad | Zendy; Ahmad Soltani | Zendy

Open Access

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Author(s) -

Hamideh Khazraiyan,

Zahra Abdi Liaei,

Hamid Emadi Koochak,

Farid Azmoudeh Ardalan,

Zahra Ahmadinejad,

Ahmad Soltani

Publication year - 2015

Publication title -

journal of the international association of providers of aids care (jiapac)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.813

H-Index - 31

eISSN - 2325-9582

pISSN - 2325-9574

DOI - 10.1177/2325957415614645

Subject(s) - medicine , concordance , quantiferon , latent tuberculosis , tuberculosis , human immunodeficiency virus (hiv) , gold standard (test) , history of tuberculosis , coinfection , mycobacterium tuberculosis , immunology , disease , pathology

Background: The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country.Methods: In a cross-sectional design,130 HIV-positive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed.Results: Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST ( P = 0.014) and QFT ( P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018).Conclusion: The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU.

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