Open AccessRecurrent Immune Reconstitution Inflammatory Syndrome of Tuberculous Brain Infection in People Living with HIV/AIDS
Author(s) -
Krishnaraj Raja,
Chandrasekar Chokkalingam,
O. R. Krishnarajasekhar,
N. Ravichandran,
Kumar Sadagopan,
M. Ayyamperumal
Publication year - 2013
Publication title -
journal of the international association of providers of aids care (jiapac)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 31
eISSN - 2325-9582
pISSN - 2325-9574
DOI - 10.1177/2325957413488170
Subject(s) - immune reconstitution inflammatory syndrome , medicine , tuberculosis , iris (biosensor) , tuberculous meningitis , brain abscess , antiretroviral therapy , immunology , incidence (geometry) , meningitis , human immunodeficiency virus (hiv) , abscess , disease , pediatrics , pathology , surgery , viral load , physics , computer security , computer science , biometrics , optics
HIV infection has changed the scenario of infectious disease. HIV-associated immunodeficiency resulted in a wide spectrum of new opportunistic infections. After introduction of antiretroviral therapy (ART), immune reconstitution inflammatory syndrome (IRIS) became an important challenge in management of 10% to 25% of the patients. Meta-analyses of IRIS from various reports published worldwide by Monika Muller et al described 12% IRIS incidence and 15.7% IRIS tuberculosis. Among IRIS tuberculosis, central nervous system involvement with IRIS tuberculous meningitis forms only 7%. Only 9 cases of tuberculous brain abscess is reported in patients with AIDS so far. The IRIS tuberculous brain abscess is very rare, and so far only 1 case is reported as a paradoxical reaction after ART initiation. Here, we report a case of recurrent IRIS tuberculosis meningitis and brain abscess.
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