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Background and Objective   An Integrative Medicine Center created a post–COVID-19 myalgiac encephalomyelitis (ME) program in response to a July 2020 Centers for Disease Control and Prevention document that described fatigue and other functional symptoms. The objective is to present process improvement data on change in health-related quality-of-life (HRQOL) in patients who participated in the “long hauler” program.Methods   For process improvement purposes, 39 consecutive patients who participated in the post–COVID-19 ME program from August 2020–August 2021 were asked to complete the 12-Item Short Form Survey (SF-12) before treatment and a month later.Results   Twelve participants (31%) completed a baseline and follow-up survey. Mean SF-12 physical component summary scores improved 5 (SD 9) and mental component summary scores improved 4 (SD 9) in patients who completed baseline and follow-up surveys. Case studies of two patients who completed the SF-12 at baseline and after 4 weekly treatments illustrate the program’s standardized treatment approach.Conclusion   Data collected for process improvement reasons describe changes in HRQOL for participants in a post–COVID-19 ME program. Follow-up practice-based clinical trials may discern optimal approaches for patients with this chronic condition.

Post-COVID-19 Long Hauler Clinical Program: Change in Health-Related Quality-of-Life