Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd (Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro | Zendy

Sidiqat A. Shodehinde | Zendy; Stephen A. Adefegha | Zendy; Ganiyu Oboh | Zendy; Sunday I. Oyeleye | Zendy; Tosin A. Olasehinde | Zendy; Emmem E. Nwanna | Zendy; Bukola C. Adedayo | Zendy; Aline Augusti Boligon | Zendy

Open Access

Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd (Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro

Author(s) -

Sidiqat A. Shodehinde,

Stephen A. Adefegha,

Ganiyu Oboh,

Sunday I. Oyeleye,

Tosin A. Olasehinde,

Emmem E. Nwanna,

Bukola C. Adedayo,

Aline Augusti Boligon

Publication year - 2016

Publication title -

journal of evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

eISSN - 2156-5872

pISSN - 2156-5899

DOI - 10.1177/2156587216636505

Subject(s) - chemistry , lipid peroxidation , bitter gourd , antioxidant , chlorogenic acid , chromatography , quercetin , sodium nitroprusside , high performance liquid chromatography , caffeic acid , gallic acid , momordica , biochemistry , nitric oxide , traditional medicine , organic chemistry , medicine

This study sought to assess the effects of bitter gourd leaf extracts (methanol and aqueous) on enzyme linked with hypertension (angiotensin-I-converting enzyme and some pro-oxidants (iron sulfate, sodium nitroprusside, and cisplatin]–induced lipid peroxidation in rat kidney homogenates. Chromatographic analysis of the extract was done using high-performance liquid chromatography–diode array detection. The results revealed that methanol extract (IC 50 = 109.63 µg/mL) had significantly ( P .05) difference in the inhibition of sodium nitroprusside–induced lipid peroxidation of both extracts. High-performance liquid chromatography–diode array detection analysis revealed the presence of quercetin, caffeic, gallic, and chlorogenic acids in the leaf. Thus, inhibition of angiotensin-I converting enzyme activity and the antioxidant properties of the extracts could be linked to the presence of phenolic phytochemicals.

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