Open AccessAntioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities
Author(s) -
Ayokunle O. Ademosun,
Ganiyu Oboh,
Fatai Bello,
Peluola O. Ayeni
Publication year - 2016
Publication title -
journal of evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
eISSN - 2156-5872
pISSN - 2156-5899
DOI - 10.1177/2156587215610032
Subject(s) - butyrylcholinesterase , rutin , acetylcholinesterase , quercetin , chemistry , aché , pharmacology , antioxidant , biochemistry , enzyme , medicine
This study sought to investigate the anticholinesterase and antioxidative properties of quercetin and its glycosylated conjugate, rutin. The in vitro inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities, inhibition of Fe 2+ -induced lipid peroxidation in rat’s brain homogenates, radicals scavenging, and Fe 2+ -chelating abilities of the flavonoids were investigated in vitro with concentrations of the samples ranging from 0.06 to 0.6 mM. Quercetin had significantly higher AChE and BChE inhibitory abilities than rutin. Quercetin also had stronger inhibition of Fe 2+ -induced lipid peroxidation in rat’s brain homogenates. Similarly, quercetin had higher radical scavenging abilities than rutin. Quercetin also had stronger Fe 2+ -chelating ability than rutin. The inhibition of cholinesterases and antioxidative properties are possible mechanisms by which the flavonoids can be used in the management of oxidative stress–induced neurodegeneration.