Open AccessThe microbiome in pancreatic diseases: Recent advances and future perspectives
Author(s) -
AmmerHerrmenau Christoph,
Pfisterer Nina,
Weingarten Mark FJ,
Neesse Albrecht
Publication year - 2020
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640620944720
Subject(s) - microbiome , medicine , pancreatic cancer , pancreatitis , biomarker discovery , human microbiome , bioinformatics , exocrine pancreas , biomarker , computational biology , gut microbiome , pancreas , cancer , biology , proteomics , gene , genetics
The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High‐throughput sequencing techniques such as next‐generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about the microbiome and its interaction with host cells and organisms. There is now emerging evidence that microorganisms also contribute to inflammatory and neoplastic diseases of the pancreas. This review summarizes current clinical and translational microbiome studies in acute and chronic pancreatitis as well as pancreatic cancer and provides evidence that the microbiome has a high potential for biomarker discovery. Furthermore, the intestinal and pancreas‐specific microbiome may also become an integrative part of diagnostic and therapeutic approaches of pancreatic diseases in the near future.