Open AccessMean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
Author(s) -
Sternby Hanna,
Mahle Mariella,
Linder Nicolas,
Erichson-Kirst Laureen,
Verdonk Robert C,
Dimova Alexandra,
Ignatavicius Povilas,
Ilzarbe Lucas,
Koiva Peeter,
Penttilä Anne,
Regnér Sara,
Bollen Thomas L,
Brill Richard,
Stangl Franz,
Wohlgemuth Walter A,
Singh Vijay,
Busse Harald,
Michl Patrick,
Beer Sebastian,
Rosendahl Jonas
Publication year - 2019
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640619882520
Subject(s) - adipose tissue , medicine , receiver operating characteristic , acute pancreatitis , odds ratio , area under the curve , muscle tissue , confidence interval , logistic regression , prospective cohort study , intra abdominal fat , gastroenterology , sarcopenia , obesity , insulin resistance , visceral fat
Background Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods In total 454 patients were recruited. The first contrast‐enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p ‐values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61–10.36, p ‐value 0.003). No body parameter presented sufficient predictive capability in ROC‐curve analysis. Conclusions Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.