Open AccessThe association between self‐reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study
Author(s) -
Jordão Haydée WT,
McKenna Gerry,
McMenamin Úna C,
Kunzmann Andrew T,
Murray Liam J,
Coleman Helen G
Publication year - 2019
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640619858043
Subject(s) - medicine , hazard ratio , gastrointestinal cancer , prospective cohort study , confidence interval , cancer , confounding , cohort study , proportional hazards model , biobank , cohort , hepatocellular carcinoma , relative risk , gastroenterology , colorectal cancer , bioinformatics , biology
Background Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due to potential confounding by smoking, alcohol and poor nutrition. The aim of this study was to investigate the association between oral health conditions and gastrointestinal cancer risk. Methods Data from the large, prospective UK Biobank cohort, which includes n = 475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self‐reported poor oral health (defined as painful gums, bleeding gums and/or having loose teeth), adjusting for confounders. Results During an average six years of follow‐up, n = 4069 gastrointestinal cancer cases were detected, of which 13% self‐reported poor oral health. Overall, there was no association between self‐reported poor oral health and risk of gastrointestinal cancer detected (hazard ratio 0.97, 95% confidence interval 0.88–1.07). In site‐specific analysis, an increased risk of hepatobiliary cancers was observed in those with self‐reported poor oral health (hazard ratio 1.32, 95% confidence interval 0.95–1.80), which was stronger for hepatocellular carcinoma (hazard ratio 1.75, 95% confidence interval 1.04–2.92). Conclusion Overall there was no association between self‐reported poor oral health and gastrointestinal cancer risk. However, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.