Open AccessAssociation of current Helicobacter pylori infection and metabolic factors with gastric cancer in 35,519 subjects: A cross‐sectional study
Author(s) -
Youn Nam Su,
Park Bum Joon,
Nam Ji Hyung,
Ryu Kum Hei,
Kook Myeong-Cherl,
Kim Jeongseon,
Lee Won Kee
Publication year - 2019
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640618819402
Subject(s) - medicine , helicobacter pylori , cross sectional study , cancer , gastroenterology , helicobacter pylori infection , helicobacter , pathology
Background The effect of current infection of Helicobacter pylori on gastric cancer has rarely been studied in a large population. We investigated the association of current H. pylori infection and metabolic factors with gastric cancer in a large population. Methods Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and H. pylori testing using gastric tissue between 2003 and 2013, were included. The association of H. pylori with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs). Results Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current H. pylori infection (OR, 2.39; 95% CI, 1.53–3.74), age (OR, 1.06; 95% CI 1.04–1.08), first‐degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30–3.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04–2.65), whereas it was inversely associated with high‐density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22–0.94). In the subanalysis, gastric cancer was associated with first‐degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39–7.50) in the absence of H. pylori , whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16–3.39) in the presence of H. pylori.Conclusions Gastric cancer was associated with current H. pylori infection, hyperglycaemia, and low HDL levels in a large population.