Open AccessInfluence of age, body mass index and comorbidity on major outcomes in acute pancreatitis, a prospective nation‐wide multicentre study
Author(s) -
Moran Robert A,
García-Rayado Guillermo,
Iglesia-García Daniel,
Martínez-Moneo Emma,
Fort-Martorell Esther,
Lauret-Braña Eugenia,
Concepción-Martín Mar,
Ausania Fabio,
Prieto-Martínez Carlos,
González-de-Cabo Miguel,
Quesada-Vázquez Noé,
Marcaide-Ruiz-de-Apodaca M Asunción,
Pajares-Díaz José A,
Díaz Francia C,
Benito José L,
Hinojosa-Guadix Jennifer,
Marqués-García Pilar,
Boadas Jaume,
Bajador-Andreu Eduardo,
Moreno Oswaldo,
Argüelles-Arias Federico,
Martín-Benítez Gregorio,
Tafur-Sánchez Carla,
Leal-Téllez Jesús,
Romero-Mosquera Beatriz,
Hernaez Ruben,
Papachristou Georgios I,
Singh Vikesh K,
Madaria Enrique
Publication year - 2018
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640618798155
Subject(s) - medicine , acute pancreatitis , body mass index , comorbidity , prospective cohort study , pancreatitis , intensive care medicine , pediatrics
Background There are few large prospective cohort studies evaluating predictors of outcomes in acute pancreatitis. Objectives The purpose of this study was to determine the role of age and co‐morbid disease in predicting major outcomes in acute pancreatitis. Methods Data points were collected according to a predefined electronic data collection form. Acute pancreatitis and its complications were defined according to the revised Atlanta classification. Univariable and multivariable analyses were conducted using Cox proportional hazard regression and multiple logistic regression. Results From June 2013–February 2015, 1655 adult patients were recruited from 23 centres across Spain. Co‐morbid disease, obesity, open surgical necrosectomy within 30 days, and pancreatic necrosis were independently associated with both 30‐day mortality and persistent organ failure ( p < 0.05 for all). Age was not associated with persistent organ failure, however the extreme of age (>85 years) was associated with mortality ( p < 0.05). Co‐morbid disease and obesity were not independently associated with a prolonged length of stay or other markers of morbidity on adjusted analysis ( p > 0.05). Conclusion Comorbidity and obesity are important determinates of mortality and persistent organ failure in acute pancreatitis, but in the absence of organ failure they do not appear to independently contribute to morbidity. This has important implications for severity classification and predictive models of severity in acute pancreatitis.