Open AccessCarbon dioxide insufflation during endoscopic resection of large colorectal polyps can reduce post‐procedure abdominal pain: A prospective, double‐blind, randomized controlled trial
Author(s) -
Kim Su Young,
Chung Jun-Won,
Kim Jung Ho,
Kim Yoon Jae,
Kim Kyoung Oh,
Kwon Kwang An,
Park Dong Kyun
Publication year - 2018
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640618776740
Subject(s) - medicine , randomized controlled trial , double blind , abdominal pain , insufflation , surgery , colonoscopy , anesthesia , abdominal surgery , colorectal cancer , placebo , cancer , alternative medicine , pathology
Background Studies of the use of CO 2 insufflation during endoscopic resection of large colorectal polyps (LCPs) are lacking. Objective We evaluated the effect of CO 2 insufflation on pain after endoscopic resection of LCPs. Methods In a prospective randomized controlled trial (RCT), 132 patients were randomly assigned to groups who underwent endoscopic resection with CO 2 insufflation (CO 2 group, n = 66) or air insufflation (air group, n = 66). The primary outcome was abdominal pain post‐procedure (PP). The secondary outcomes were abdominal distension, rates of technical success, amounts of sedatives prescribed, use of analgesics, and adverse events. Results Baseline patient characteristics were similar between the groups. The mean abdominal pain score was 12.3 in the CO 2 group vs. 17.5 in the air group at 1 h PP ( p = 0.047). Also, the proportion of patients without pain was significantly higher in the CO 2 group at 1 h PP ( p = 0.008). The pain score differed more in the endoscopic submucosal dissection group and long‐time group. The secondary outcomes were not significantly different between the two groups. Conclusions The results of this RCT demonstrate the superiority of CO 2 insufflation for endoscopic resection of LCPs in terms of decreasing PP abdominal pain (KCT0001636).