Open AccessUse of volumetric laser endomicroscopy for determining candidates for endoscopic therapy in superficial esophageal squamous cell carcinoma
Author(s) -
Trindade Arvind J,
Benias Petros C,
Inamdar Sumant,
Fan Cathy,
Sethi Amrita,
Fukami Norio,
Kahn Allon,
Kahaleh Michel,
Andalib Iman,
Sejpal Divyesh V,
Rishi Arvind
Publication year - 2018
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640618761701
Subject(s) - medicine , endomicroscopy , endoscopy , lamina propria , endoscopic ultrasound , radiology , endoscopic mucosal resection , pathology , confocal , epithelium , geometry , mathematics
Background Accurate staging of superficial esophageal squamous cell cancer (ESCC) for endoscopic therapy is challenging. Optical coherence tomography (OCT) has been shown to be superior to high‐resolution endoscopic ultrasound (EUS). Volumetric Laser Endomicroscopy (VLE), a second‐generation OCT, has recently become commercially available. Objective To assess if VLE can determine which patients with superficial ESSC can undergo endoscopic therapy. Methods This is a multi‐center retrospective study. Patients were included if (a) they had visible ESCC, (b) they underwent VLE and EUS for staging, and c) if superficial disease was suspected then endoscopic resection had to be performed to have accurate histology to compare the VLE scan to. VLE scans were then compared to the gold standard: histology for superficial disease and EUS for disease T1b and greater. Results Seventeen patients were included with the following disease: squamous intraepithelial neoplasia (4 patients), T1a disease (6 patients), T1b (2 patients), T2 disease (2 patients) and T3 disease (3 patients). VLE was able to distinguish superficial disease, defined as disease limited up to the lamina propria, from non‐superficial disease in all cases. Conclusions VLE may be able to determine which ESCC patients are candidates for endoscopic therapy. Prospective studies are needed to confirm this.