Open AccessReal‐time diagnosis of H. pylori infection during endoscopy: Accuracy of an innovative tool (EndoFaster)
Author(s) -
Costamagna Guido,
Zullo Angelo,
Bizzotto Alessandra,
Spada Cristiano,
Hassan Cesare,
Riccioni Maria Elena,
Marmo Clelia,
Strangio Giuseppe,
Di Rienzo Teresa Antonella,
Cammarota Giovanni,
Gasbarrini Antonio,
Repici Alessandro
Publication year - 2016
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640615610021
Subject(s) - medicine , gold standard (test) , gastroenterology , endoscopy , predictive value , diagnostic accuracy , urea breath test , helicobacter pylori , predictive value of tests , helicobacter pylori infection
Background EndoFaster is novel device able to perform real‐time ammonium measurement in gastric juice allowing H. pylori diagnosis during endoscopy. This large study aimed to validate the accuracy of EndoFaster for real‐time H. pylori detection. Methods Consecutive patients who underwent upper endoscopy in two centres were prospectively enrolled. During endoscopy, 4 ml of gastric juice were aspirated to perform automatic analysis by EndoFaster within 90 seconds, and H. pylori was considered present (>62 ppm/ml) or absent (≤62 ppm/ml). Accuracy was measured by using histology as gold standard, and 13 C‐urea breath test (UBT) in discordant cases. Accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) were calculated. Results Overall, 189 patients were enrolled, but in seven (3.4%) the aspirated gastric juice amount was insufficient to perform the test. The accuracy, sensitivity, specificity, PPV, and NPV were 87.4%, 90.3%, 85.5%, 80.2%, 93.1%, respectively, and 92.6%, 97.1%, 89.7%, 85.9%, 98.0%, respectively, when H. pylori status was reclassified according to the UBT result in discordant cases. Conclusions This study found a high accuracy/feasibility of EndoFaster for real‐time H. pylori diagnosis. Use of EndoFaster may allow selecting those patients in whom routine gastric biopsies could be avoided.