Open AccessEffects of carbon dioxide insufflation in balloon‐assisted enteroscopy: A systematic review and meta‐analysis
Author(s) -
Nishizawa Toshihiro,
Suzuki Hidekazu,
Fujimoto Ai,
Ochiai Yasutoshi,
Kanai Takanori,
Naohisa Yahagi
Publication year - 2016
Publication title -
ueg journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 35
eISSN - 2050-6414
pISSN - 2050-6406
DOI - 10.1177/2050640615588024
Subject(s) - medicine , meta analysis , enteroscopy , insufflation , balloon , radiology , surgery , endoscopy
Background and aim The efficacy of CO 2 insufflation during balloon‐assisted enteroscopy remains controversial. This study aimed to perform a systematic review with meta‐analysis of randomized controlled trials (RCTs) in which CO 2 insufflation was compared with air insufflation in balloon‐assisted enteroscopy. Methods PubMed, the Cochrane library, and the Igaku‐Chuo‐Zasshi database were searched to identify RCTs eligible for inclusion in the systematic review. Data from the eligible studies were combined to calculate the pooled odds ratios (ORs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs). Results Four RCTs (461 patients) were identified. Compared with air insufflation, CO 2 insufflation significantly increased intubation depth of oral enteroscopy (WMD: 55.2, 95% CI: 10.77–99.65, p = 0.015). However, there was significant heterogeneity. The intubation depth of anal enteroscopy showed no significant difference between the CO 2 group and the air group. CO 2 insufflation significantly reduced abdominal pain compared with air insufflation (WMD: −2.463, 95% CI: −4.452 to −0.474, p = 0.015), without significant heterogeneity. The PaCO 2 or end‐tidal CO 2 level showed no significant difference between the CO 2 group and air group. Conclusions Compared with air insufflation, CO 2 insufflation during balloon‐assisted enteroscopy caused less post‐procedural pain without CO 2 retention.