Open AccessDetection of dengue virus serotype 1 in central nervous system of a child in Bandung, West Java: A case report
Author(s) -
Dewi Hawani Alisjahbana,
Syndi Nurmawati,
Dzulfikar Dl Hakim,
Mia Milanti,
Yora Permata Dewi,
Edison Johar,
Khin Saw Aye Myint,
Jeremy P Lederman,
Ann M. Powers,
Bachti Alisjahbana,
Ungke Antonjaya
Publication year - 2021
Publication title -
sage open medical case reports
Language(s) - English
Resource type - Journals
ISSN - 2050-313X
DOI - 10.1177/2050313x211034393
Subject(s) - dengue virus , dengue fever , serotype , medicine , virology , serology , virus , encephalitis , central nervous system , japanese encephalitis , flavivirus , antibody , immunology
Central nervous system involvement of dengue virus is increasingly reported from endemic areas. This study describes the clinical characteristics and laboratory features of a pediatric patient enrolled in a central nervous system illness study conducted in 2017–2018 to identify viral and bacterial etiologies in Indonesian children. Dengue diagnostics including molecular and serological testing were performed on an encephalitis patient who presented with both classical dengue and neurological clinical symptoms. Dengue virus serotype 1 RNA was detected in both cerebrospinal fluid and serum by serotype-specific reverse transcription polymerase chain reaction, and the E gene was successfully sequenced. Anti-dengue virus immunoglobulin M was detected in both admission and discharge sera, whereas anti-dengue virus immunoglobulin G was identified only in the discharge serum. This study describes the central nervous system complications in a case with dengue virus infection in West Java, Indonesia, and highlights the potential for dengue virus serotype 1, a serotype rarely associated with neurotropism, to cause encephalitis.