Open AccessLiver abnormalities in pulmonary arterial hypertension
Author(s) -
Nickel Nils P.,
Galura Gian M.,
Zuckerman Marc J.,
Hakim M. Nawar,
Alkhateeb Haider,
Mukherjee Debabrata,
Austin Eric D.,
Heresi Gustavo A.
Publication year - 2021
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/20458940211054304
Subject(s) - medicine , pulmonary hypertension , heart failure , systemic circulation , liver disease , lipid metabolism , cardiology , disease , pathology
Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In recent years, it has been recognized that PAH is a multi‐organ system disease, involving the systemic circulation, kidneys, skeletal muscles, and the central nervous system, among others. Right heart failure produces congestive hepatopathy, a disease state that has direct consequences on liver biochemistry, histology, and systemic glucose and lipid metabolism. This article aims to summarize the consequences of congestive hepatopathy with an emphasis on liver biochemistry, histology, and PAH‐targeted therapy. Furthermore, PAH‐specific changes in glucose and lipid metabolism will be discussed.