Open AccessBMPR2 mutations and response to inhaled or parenteral prostanoids: a case series
Author(s) -
Scelsi Laura,
Greco Alessandra,
Acquaro Mauro,
Olivieri Carla,
Sobrero Matteo,
Turco Annalisa,
Cappelletti Donata,
Visconti Luigi Oltrona,
Ghio Stefano
Publication year - 2021
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/20458940211037275
Subject(s) - bmpr2 , medicine , prostanoid , mutation , haemodynamic response , gene , genetics , receptor , heart rate , biology , bone morphogenetic protein , blood pressure
Whether mutations in the BMPR2 gene may influence the response to PAH‐specific therapies has not yet been investigated. In this study, in 13 idiopathic, heritable or anorexigen‐associated PAH patients, in whom treatment escalation was performed by adding a prostanoid, a greater haemodynamic improvement was observed in BMPR2‐negative than in BMPR2‐positive patients.