Open AccessThe mechanism of ions in pulmonary hypertension
Author(s) -
Liu Guoyu,
Fu Daiyan,
Tian Heshen,
Dai Aiguo
Publication year - 2021
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894020987948
Subject(s) - medicine , pathogenesis , pulmonary hypertension , vasoconstriction , hypoxic pulmonary vasoconstriction , vascular smooth muscle , apoptosis , inflammation , calcium , ion , sodium , biophysics , biochemistry , chemistry , biology , smooth muscle , organic chemistry
Pulmonary hypertensionPHis a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions play a major role in the pathogenesis of PH. Many vasoactive substances, inflammatory mediators, transcription‐inducing factors, apoptosis mediators, redox substances and translation modifiers can control the concentration of ions inside and outside the cell by regulating the activity of ion channels, which can regulate vascular contraction, cell proliferation, migration, apoptosis, inflammation and other functions. We all know that there are no effective drugs to treat PH. Ions are involved in the occurrence and development of PH, so it is necessary to clarify the mechanism of ions in PH as a therapeutic target for PH. The main ions involved in PH are calcium ion (Ca 2+ ), potassium ion (K + ), sodium ion (Na + ) and chloride ion (Cl – ). Here, we mainly discuss the distribution of these ions and their channels in pulmonary arteries and their role in the pathogenesis of PH.