Open AccessIncident pulmonary arterial hypertension associated with Bosutinib
Author(s) -
Yo Shaun,
Thenganatt John,
Lipton Jeffrey,
Granton John
Publication year - 2020
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894020936913
Subject(s) - bosutinib , medicine , dasatinib , pulmonary hypertension , cardiology , tyrosine kinase inhibitor , pulmonary toxicity , myeloid leukemia , lung , imatinib , cancer
Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug‐induced pulmonary arterial hypertension. There have been case reports linking Bosutinib with deterioration of pre‐existing pulmonary arterial hypertension. Here, we present a case of a 37‐year‐old woman with chronic myeloid leukemia treated with Bosutinib who was diagnosed with pulmonary arterial hypertension. Prior to Bosutinib, she had received Dasatinib without documented cardiopulmonary toxicity. Withdrawal of Bosutinib led to partial reversal of pulmonary arterial hypertension, and with the addition of pulmonary arterial hypertension‐targeted treatment, there was near normalization of hemodynamics.