Open AccessEvidence of pulmonary arterial hypertension in two patients with common variable immunodeficiency
Author(s) -
Huston Jessica,
Johnson Joyce,
Hemnes Anna,
Pugh Meredith
Publication year - 2020
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894020922792
Subject(s) - common variable immunodeficiency , medicine , malignancy , complication , disease , pulmonary hypertension , immunodeficiency , immunology , intensive care medicine , antibody , immune system
Common variable immunodeficiency is a chronic illness plagued with recurrent infections and the potential to develop autoimmune disease. These patients may manifest a spectrum of complications ranging from hematologic malignancy to chronic parenchymal lung disease. Regular immunoglobulin replacement therapy improves immunologic debility but does not mitigate other features of this disease. Here, we discuss a complication of common variable immunodeficiency not previously characterized in the literature. We present two cases of advanced pulmonary vascular disease associated with common variable immunodeficiency treated with pulmonary vasodilators.