Open AccessLightwave-reinforced stem cells with enhanced wound healing efficacy
Author(s) -
Hye Ran Jeon,
Sung-Won Kim,
Yeong Hwan Kim,
GwangBum Im,
Jisoo Im,
Soong Ho Um,
Sung Min Cho,
JuRo Lee,
Han Young Kim,
Yoon Ki Joung,
Dong Ik Kim,
Suk Ho Bhang
Publication year - 2021
Publication title -
journal of tissue engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.436
H-Index - 30
ISSN - 2041-7314
DOI - 10.1177/20417314211067004
Subject(s) - mesenchymal stem cell , stem cell , wound healing , adipose tissue , angiogenesis , regeneration (biology) , microbiology and biotechnology , in vitro , cancer research , medicine , chemistry , biology , immunology , biochemistry
Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.