Open AccessNew composition of tungsten has a broad range of antiviral activity
Author(s) -
Hranush Avagyan,
Anaida Mirzoyan,
Ferdinand Mirzoyan,
Roza Izmailyan,
Svetlana Hakobyan,
H. Voskanyan,
Zara B. Semerjyan,
A. A. Avetisyan,
Hranush Arzumanyan,
Е М Каралова,
Liana Abroyan,
Lilit Hakobyan,
Nane Bayramyan,
Nazeli Gevorgyan,
Alexander Karalyan,
Zaven Karalyan
Publication year - 2022
Publication title -
antiviral chemistry and chemotherapy
Language(s) - English
Resource type - Journals
eISSN - 2040-2066
pISSN - 0956-3202
DOI - 10.1177/20402066221090061
Subject(s) - virus , virology , biology , in vivo , vaccinia , influenza a virus , in vitro , hepatitis c virus , antiviral drug , microbiology and biotechnology , biochemistry , gene , recombinant dna
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na 2 WO 4 × 2H 2 O and Aluminum sulfate octadecahydrate-Al 2 (SO 4 ) 3 × 18H 2 O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect.