Open AccessPolymorphous low-grade neuroepithelial tumor of the young: Rare tumor and review of the literature
Author(s) -
Ali H. Palejwala,
Christen M. O’Neal,
Michael Quinton,
James Battiste,
Jo Elle G. Peterson,
Ian F. Dunn
Publication year - 2022
Publication title -
rare tumors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.285
H-Index - 15
eISSN - 2036-3613
pISSN - 2036-3605
DOI - 10.1177/20363613221083360
Subject(s) - neuroepithelial cell , medicine , pathology , cd34 , histology , epilepsy , radiology , stem cell , biology , genetics , neural stem cell , psychiatry
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described low-grade neuroepithelial tumor with an infiltrative growth pattern and oligodendrocyte-like cells that are CD34 immunopositive. Correlating histology and results from molecular testing is critical to correctly diagnosing PLNTY, as its histologic appearance is similar to oligodendrogliomas and shares genetic abnormalities common to other low-grade epilepsy associated tumors (LEATs). In this case report, we describe a 31-year-old female with intractable epilepsy found to have a temporal mass and diagnosed with PLNTY after histopathologic and molecular testing. We describe the radiographic, histologic, and genetic features in relation to the epileptic and oncologic outcomes for this patient. Then, we compare these features and outcomes to other cases of PLNTY described in the literature.