Open AccessBone Turnover Markers
Author(s) -
Clementine Yf Yap,
Tar Choon Aw
Publication year - 2010
Publication title -
proceedings of singapore healthcare
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
eISSN - 2059-2329
pISSN - 2010-1058
DOI - 10.1177/201010581001900315
Subject(s) - bone remodeling , osteocalcin , n terminal telopeptide , bone resorption , bone mineral , procollagen peptidase , endocrinology , morning , medicine , resorption , type i collagen , chemistry , alkaline phosphatase , osteoporosis , biochemistry , enzyme
Bone turnover markers (BTM) provide useful data to titrate the optimal dosing regimes for patients within 3–6 months as compared to 1–2 years using bone mineral density (BMD). Serum obtained under standardised conditions (fasting, early morning) should be tested using a precise automated immunoassay for a panel of bone markers that includes a resorption marker — C-terminal cross-linked telopeptide of bone collagen (CTX) — and formation markers — Procollagen Type 1 N-terminal Propeptide (P1NP) and Osteocalcin (OC).